{ "dataDate": "2026-09-18", "finding": "As of 18 September 2026, 10 of the 51 completed essential tremor trials that never posted results to ClinicalTrials.gov, and are at least twelve months past completion, have no results publication that could be located; those 10 trials enrolled 338 participants.", "caveat": "This is a literature search outcome, not a finding that results were never published.", "source": { "site": "https://et-trials-tracker.xyz/", "repository": "https://github.com/joooord/et-trials-tracker", "licence": "https://creativecommons.org/licenses/by/4.0/", "registry": "ClinicalTrials.gov" }, "headline": { "registered": { "count": 192, "participants": 10764 }, "completed": { "count": 92, "participants": 4446 }, "postedResults": { "count": 35, "participants": 2338 }, "noResultsPosted": { "count": 57, "participants": 2108 }, "pastTwelveMonths": { "count": 51, "participants": 1982 }, "insideTwelveMonths": { "count": 6, "participants": 126 }, "studiesWithoutEnrolment": 11 }, "dueBreakdown": [ { "key": "FOUND_RESULTS", "label": "Results publication located", "count": 30, "participants": 1178, "percentOfDue": 59 }, { "key": "MENTIONED_ONLY", "label": "Cited in literature only", "count": 6, "participants": 422, "percentOfDue": 12 }, { "key": "NOT_FOUND", "label": "No results publication located", "count": 10, "participants": 338, "percentOfDue": 20 }, { "key": "UNCERTAIN", "label": "Uncertain", "count": 5, "participants": 44, "percentOfDue": 10 } ], "trials": [ { "nct_id": "NCT00001986", "title": "1-Octanol to Treat Essential Tremor", "conditions": "Essential Tremor", "status": "COMPLETED", "phase": "PHASE1", "start_date": "2000-01", "completion_date": "2001-01", "months_since_completion": "308", "enrollment": "12", "sponsor_name": "National Institute of Neurological Disorders and Stroke (NINDS)", "sponsor_class": "NIH", "sponsor_class_label": "NIH", "results_posted": "no", "due_12m": "yes", "classification": "FOUND_RESULTS", "classification_label": "Results publication located", "match_basis": "SPECIFICS_MATCH", "pmid": "14718713", "doi": "10.1212/01.wnl.0000101722.95137.19", "url_opened": "https://pubmed.ncbi.nlm.nih.gov/14718713/", "pub_title": "Pilot trial of 1-octanol in essential tremor", "pub_year": "2004", "journal": "Neurology", "rationale": "No NCT-ID hit reports it (only a 2020 review cites the ID); Bushara/Hallett NIH paper matches registry exactly: randomized placebo-controlled single-dose 1 mg/kg 1-octanol, 12 ET patients, NINDS, 2000-2001", "registry_url": "https://clinicaltrials.gov/study/NCT00001986", "anchor": "https://et-trials-tracker.xyz/#NCT00001986" }, { "nct_id": "NCT00018564", "title": "Novel Therapies for Essential Tremor", "conditions": "Essential Tremor", "status": "COMPLETED", "phase": "PHASE3", "start_date": "2000-10", "completion_date": "2003-09", "months_since_completion": "276", "enrollment": "", "sponsor_name": "US Department of Veterans Affairs", "sponsor_class": "FED", "sponsor_class_label": "Other federal", "results_posted": "no", "due_12m": "yes", "classification": "UNCERTAIN", "classification_label": "Uncertain", "match_basis": "NONE", "pmid": "15390011", "doi": "10.1002/mds.20147", "url_opened": "https://pubmed.ncbi.nlm.nih.gov/15390011/", "pub_title": "Pilot efficacy and tolerability: a randomized placebo-controlled trial of levetiracetam for essential tremor", "pub_year": "2004", "journal": "Mov Disord", "rationale": "Registry is an umbrella VA program record (drug unnamed) at VA Greater Los Angeles; Handforth & Martin 2004 levetiracetam RCT fits design and window but cannot be tied to this record specifically", "registry_url": "https://clinicaltrials.gov/study/NCT00018564", "anchor": "https://et-trials-tracker.xyz/#NCT00018564" }, { "nct_id": "NCT00236496", "title": "A Comparison of the Efficacy and Safety of Topiramate Versus Placebo in Treating Tremor of Unknown Cause.", "conditions": "Essential Tremor", "status": "COMPLETED", "phase": "PHASE3", "start_date": "2001-10", "completion_date": "2004-02", "months_since_completion": "271", "enrollment": "223", "sponsor_name": "Johnson & Johnson Pharmaceutical Research & Development, L.L.C.", "sponsor_class": "INDUSTRY", "sponsor_class_label": "Industry", "results_posted": "no", "due_12m": "yes", "classification": "FOUND_RESULTS", "classification_label": "Results publication located", "match_basis": "SPECIFICS_MATCH", "pmid": "16436648", "doi": "10.1212/01.wnl.0000200779.03748.0f", "url_opened": "https://pubmed.ncbi.nlm.nih.gov/16436648/", "pub_title": "Topiramate in essential tremor: a double-blind placebo-controlled trial", "pub_year": "2006", "journal": "Neurology", "rationale": "No NCT-ID hits; Ondo 2006 (Ortho-McNeil supported, multicenter, 24 weeks, TRS primary, ITT 208 vs 223 enrolled) matches the registry design", "registry_url": "https://clinicaltrials.gov/study/NCT00236496", "anchor": "https://et-trials-tracker.xyz/#NCT00236496" }, { "nct_id": "NCT00016679", "title": "1-Octanol to Treat Essential Tremor", "conditions": "Essential Tremor", "status": "COMPLETED", "phase": "PHASE1", "start_date": "2001-05", "completion_date": "2004-03", "months_since_completion": "270", "enrollment": "42", "sponsor_name": "National Institute of Neurological Disorders and Stroke (NINDS)", "sponsor_class": "NIH", "sponsor_class_label": "NIH", "results_posted": "no", "due_12m": "yes", "classification": "FOUND_RESULTS", "classification_label": "Results publication located", "match_basis": "SPECIFICS_MATCH", "pmid": "15210907", "doi": "10.1212/wnl.62.12.2320", "url_opened": "https://pubmed.ncbi.nlm.nih.gov/15210907/", "pub_title": "Open-label dose-escalation study of oral 1-octanol in patients with essential tremor", "pub_year": "2004", "journal": "Neurology", "rationale": "No NCT-ID hits; NINDS phase Ia dose escalation; Shill/Hallett 2004 reports exactly that design; enrolment 42 vs 21 dosed is the only discrepancy", "registry_url": "https://clinicaltrials.gov/study/NCT00016679", "anchor": "https://et-trials-tracker.xyz/#NCT00016679" }, { "nct_id": "NCT00080366", "title": "Octanol to Treat Essential Tremor", "conditions": "Essential Tremor", "status": "COMPLETED", "phase": "PHASE2", "start_date": "2004-03", "completion_date": "2007-03", "months_since_completion": "234", "enrollment": "14", "sponsor_name": "National Institute of Neurological Disorders and Stroke (NINDS)", "sponsor_class": "NIH", "sponsor_class_label": "NIH", "results_posted": "no", "due_12m": "yes", "classification": "UNCERTAIN", "classification_label": "Uncertain", "match_basis": "NONE", "pmid": "21594724", "doi": "10.1007/s13311-011-0045-1", "url_opened": "https://pubmed.ncbi.nlm.nih.gov/21594724/", "pub_title": "An open-label single-dose crossover study of the pharmacokinetics and metabolism of two oral formulations of 1-octanol in patients with essential tremor", "pub_year": "2011", "journal": "Neurotherapeutics", "rationale": "Nahab/Hallett 2011 has exactly 14 participants in window, but registry describes double-blind placebo crossover whereas paper is open-label PK; design mismatch prevents confirmation", "registry_url": "https://clinicaltrials.gov/study/NCT00080366", "anchor": "https://et-trials-tracker.xyz/#NCT00080366" }, { "nct_id": "NCT00524056", "title": "A Proof of Concept Study of the Effectiveness of Carisbamate in the Treatment of Essential Tremor", "conditions": "Essential Tremor, Movement Disorders", "status": "COMPLETED", "phase": "PHASE2", "start_date": "2007-08", "completion_date": "2008-03", "months_since_completion": "222", "enrollment": "62", "sponsor_name": "SK Life Science, Inc.", "sponsor_class": "INDUSTRY", "sponsor_class_label": "Industry", "results_posted": "no", "due_12m": "yes", "classification": "FOUND_RESULTS", "classification_label": "Results publication located", "match_basis": "NCT_ID_MATCH", "pmid": "20201005", "doi": "10.1002/mds.22872", "url_opened": "https://pubmed.ncbi.nlm.nih.gov/20201005/", "pub_title": "Carisbamate in essential tremor: brief report of a proof of concept study", "pub_year": "2010", "journal": "Mov Disord", "rationale": "PubMed secondary-source-ID match; 62-patient randomized double-blind crossover carisbamate vs placebo", "registry_url": "https://clinicaltrials.gov/study/NCT00524056", "anchor": "https://et-trials-tracker.xyz/#NCT00524056" }, { "nct_id": "NCT00620165", "title": "Efficacy of Levetiracetam in Essential Tremor", "conditions": "Essential Tremor", "status": "COMPLETED", "phase": "PHASE1|PHASE2", "start_date": "2005-01", "completion_date": "2008-03", "months_since_completion": "222", "enrollment": "10", "sponsor_name": "Southern California Institute for Research and Education", "sponsor_class": "OTHER", "sponsor_class_label": "Other", "results_posted": "no", "due_12m": "yes", "classification": "NOT_FOUND", "classification_label": "No results publication located", "match_basis": "NONE", "pmid": "", "doi": "", "url_opened": "https://pubmed.ncbi.nlm.nih.gov/18090460/", "pub_title": "", "pub_year": "", "journal": "", "rationale": "No NCT-ID hits; all 15 levetiracetam-ET papers 2004-2014 opened; none from VA Long Beach or matching a 10-patient triple-blind RCT", "registry_url": "https://clinicaltrials.gov/study/NCT00620165", "anchor": "https://et-trials-tracker.xyz/#NCT00620165" }, { "nct_id": "NCT00439699", "title": "A Pilot Clinical Trial Of Memantine for Essential Tremor", "conditions": "Essential Tremor", "status": "COMPLETED", "phase": "PHASE4", "start_date": "2007-02", "completion_date": "2009-12", "months_since_completion": "201", "enrollment": "16", "sponsor_name": "VA Greater Los Angeles Healthcare System", "sponsor_class": "FED", "sponsor_class_label": "Other federal", "results_posted": "no", "due_12m": "yes", "classification": "FOUND_RESULTS", "classification_label": "Results publication located", "match_basis": "SPECIFICS_MATCH", "pmid": "20838216", "doi": "10.1097/WNF.0b013e3181ebd109", "url_opened": "https://pubmed.ncbi.nlm.nih.gov/20838216/", "pub_title": "A pilot efficacy and tolerability trial of memantine for essential tremor", "pub_year": "2010", "journal": "Clin Neuropharmacol", "rationale": "Handforth (VA GLA) open memantine trial: 16 enrolled 13 evaluable, non-randomized, matching registry", "registry_url": "https://clinicaltrials.gov/study/NCT00439699", "anchor": "https://et-trials-tracker.xyz/#NCT00439699" }, { "nct_id": "NCT01334814", "title": "Chronic Versus Intermittent Deep Brain Stimulation for Essential Tremor", "conditions": "Essential Tremor", "status": "COMPLETED", "phase": "NA", "start_date": "2002-01", "completion_date": "2010-01", "months_since_completion": "200", "enrollment": "8", "sponsor_name": "Mayo Clinic", "sponsor_class": "OTHER", "sponsor_class_label": "Other", "results_posted": "no", "due_12m": "yes", "classification": "MENTIONED_ONLY", "classification_label": "Cited in literature only", "match_basis": "NONE", "pmid": "38004040", "doi": "10.3390/medicina59111991", "url_opened": "https://pubmed.ncbi.nlm.nih.gov/38004040/", "pub_title": "Deep Brain Stimulation for the Management of Refractory Neurological Disorders: A Comprehensive Review", "pub_year": "2023", "journal": "Medicina (Kaunas)", "rationale": "Only hit is a 2023 narrative review citing the NCT ID; no Mayo results paper for intermittent vs continuous VIM DBS in 8 ET patients", "registry_url": "https://clinicaltrials.gov/study/NCT01334814", "anchor": "https://et-trials-tracker.xyz/#NCT01334814" }, { "nct_id": "NCT00584376", "title": "Pregabalin (Lyrica) for the Treatment of Essential Tremor", "conditions": "Essential Tremor", "status": "COMPLETED", "phase": "PHASE4", "start_date": "2007-12", "completion_date": "2010-11", "months_since_completion": "190", "enrollment": "29", "sponsor_name": "University of South Florida", "sponsor_class": "OTHER", "sponsor_class_label": "Other", "results_posted": "no", "due_12m": "yes", "classification": "FOUND_RESULTS", "classification_label": "Results publication located", "match_basis": "SPECIFICS_MATCH", "pmid": "23238907", "doi": "10.1002/mds.25264", "url_opened": "https://pubmed.ncbi.nlm.nih.gov/23238907/", "pub_title": "Multisite double-blind randomized controlled study of pregabalin for essential tremor", "pub_year": "2012", "journal": "Mov Disord", "rationale": "Zesiewicz (USF) research letter with coauthors from the registry sites matches the multisite double-blind randomized crossover design and PI; letter format without abstract", "registry_url": "https://clinicaltrials.gov/study/NCT00584376", "anchor": "https://et-trials-tracker.xyz/#NCT00584376" }, { "nct_id": "NCT01332695", "title": "A Pilot Efficacy and Safety Study of ST101 in Essential Tremor", "conditions": "Essential Tremor", "status": "COMPLETED", "phase": "PHASE2", "start_date": "2011-04", "completion_date": "2011-12", "months_since_completion": "177", "enrollment": "25", "sponsor_name": "Sonexa Therapeutics, Inc.", "sponsor_class": "INDUSTRY", "sponsor_class_label": "Industry", "results_posted": "no", "due_12m": "yes", "classification": "NOT_FOUND", "classification_label": "No results publication located", "match_basis": "NONE", "pmid": "", "doi": "", "url_opened": "https://pubmed.ncbi.nlm.nih.gov/35750361/", "pub_title": "", "pub_year": "", "journal": "", "rationale": "No NCT-ID hits; PubMed and Europe PMC searches for ST101/ZSET1446/Sonexa and tremor return no clinical paper", "registry_url": "https://clinicaltrials.gov/study/NCT01332695", "anchor": "https://et-trials-tracker.xyz/#NCT01332695" }, { "nct_id": "NCT01223144", "title": "Decision-making and Emotion Recognition in Essential Tremor", "conditions": "Essential Tremor", "status": "COMPLETED", "phase": "NA", "start_date": "2010-09", "completion_date": "2011-12", "months_since_completion": "177", "enrollment": "39", "sponsor_name": "University Hospital, Bordeaux", "sponsor_class": "OTHER", "sponsor_class_label": "Other", "results_posted": "no", "due_12m": "yes", "classification": "FOUND_RESULTS", "classification_label": "Results publication located", "match_basis": "SPECIFICS_MATCH", "pmid": "24178244", "doi": "10.1007/s00702-013-1110-1", "url_opened": "https://pubmed.ncbi.nlm.nih.gov/24178244/", "pub_title": "Facial emotion recognition is inversely correlated with tremor severity in essential tremor", "pub_year": "2013", "journal": "J Neural Transm (Vienna)", "rationale": "Auzou/Meissner CHU Bordeaux paper uses the Ekman task and Iowa Gambling Task in 20 ET + 18 controls (38 vs 39 registered), matching intervention, site, PI and timing", "registry_url": "https://clinicaltrials.gov/study/NCT01223144", "anchor": "https://et-trials-tracker.xyz/#NCT01223144" }, { "nct_id": "NCT01468948", "title": "Octanoic Acid for Essential Tremor", "conditions": "Essential Tremor", "status": "COMPLETED", "phase": "PHASE1", "start_date": "2011-10-28", "completion_date": "2012-07-18", "months_since_completion": "170", "enrollment": "18", "sponsor_name": "National Institute of Neurological Disorders and Stroke (NINDS)", "sponsor_class": "NIH", "sponsor_class_label": "NIH", "results_posted": "no", "due_12m": "yes", "classification": "FOUND_RESULTS", "classification_label": "Results publication located", "match_basis": "NCT_ID_MATCH", "pmid": "26927672", "doi": "10.1172/JCI83621", "url_opened": "https://pubmed.ncbi.nlm.nih.gov/26927672/", "pub_title": "Dose-escalation study of octanoic acid in patients with essential tremor", "pub_year": "2016", "journal": "J Clin Invest", "rationale": "NCT ID stated in abstract; open-label 3+3 dose escalation at NINDS matches registry", "registry_url": "https://clinicaltrials.gov/study/NCT01468948", "anchor": "https://et-trials-tracker.xyz/#NCT01468948" }, { "nct_id": "NCT01304758", "title": "ExAblate Transcranial MR Guided Focused Ultrasound in the Treatment of Essential Tremor", "conditions": "Essential Tremor", "status": "COMPLETED", "phase": "PHASE1", "start_date": "2011-01", "completion_date": "2012-10", "months_since_completion": "167", "enrollment": "15", "sponsor_name": "InSightec", "sponsor_class": "INDUSTRY", "sponsor_class_label": "Industry", "results_posted": "no", "due_12m": "yes", "classification": "FOUND_RESULTS", "classification_label": "Results publication located", "match_basis": "NCT_ID_MATCH", "pmid": "23944301", "doi": "10.1056/NEJMoa1300962", "url_opened": "https://pubmed.ncbi.nlm.nih.gov/23944301/", "pub_title": "A pilot study of focused ultrasound thalamotomy for essential tremor", "pub_year": "2013", "journal": "N Engl J Med", "rationale": "NCT ID stated in abstract; 15-patient UVA ExAblate feasibility study matches registry", "registry_url": "https://clinicaltrials.gov/study/NCT01304758", "anchor": "https://et-trials-tracker.xyz/#NCT01304758" }, { "nct_id": "NCT01579435", "title": "Experimental Therapeutics in Essential Tremor Using Transcranial Direct Current Stimulation", "conditions": "Essential Tremor", "status": "COMPLETED", "phase": "NA", "start_date": "2012-04", "completion_date": "2013-04", "months_since_completion": "161", "enrollment": "12", "sponsor_name": "Institut National de la Santé Et de la Recherche Médicale, France", "sponsor_class": "OTHER_GOV", "sponsor_class_label": "Other government", "results_posted": "no", "due_12m": "yes", "classification": "NOT_FOUND", "classification_label": "No results publication located", "match_basis": "NONE", "pmid": "", "doi": "", "url_opened": "https://pubmed.ncbi.nlm.nih.gov/24582371/", "pub_title": "", "pub_year": "", "journal": "", "rationale": "All tDCS-in-ET papers 2013-2026 opened; none from Pitie-Salpetriere (Roze) with cerebellar vs motor-cortex tDCS in 12 ET patients", "registry_url": "https://clinicaltrials.gov/study/NCT01579435", "anchor": "https://et-trials-tracker.xyz/#NCT01579435" }, { "nct_id": "NCT01932463", "title": "ExAblate (Magnetic Resonance-guided Focused Ultrasound Surgery) for Treatment of Tremor", "conditions": "Tremor; Essential Tremor", "status": "COMPLETED", "phase": "NA", "start_date": "2011-05", "completion_date": "2013-07", "months_since_completion": "158", "enrollment": "6", "sponsor_name": "InSightec", "sponsor_class": "INDUSTRY", "sponsor_class_label": "Industry", "results_posted": "no", "due_12m": "yes", "classification": "FOUND_RESULTS", "classification_label": "Results publication located", "match_basis": "SPECIFICS_MATCH", "pmid": "23523144", "doi": "10.1016/S1474-4422(13)70048-6", "url_opened": "https://europepmc.org/article/MED/23523144", "pub_title": "MR-guided focused ultrasound thalamotomy for essential tremor: a proof-of-concept study", "pub_year": "2013", "journal": "Lancet Neurol", "rationale": "Lipsman/Schwartz Sunnybrook 4-patient study fits the Sunnybrook ExAblate feasibility window; PMID 35995551 (JNNP 2022) explicitly lists NCT01932463 among its registrations in a pooled analysis", "registry_url": "https://clinicaltrials.gov/study/NCT01932463", "anchor": "https://et-trials-tracker.xyz/#NCT01932463" }, { "nct_id": "NCT01764815", "title": "Evaluation of Directional Stimulation During the Implantation of Deep Brain Stimulation (DBS) Leads", "conditions": "Parkinson's Disease; Essential Tremor", "status": "COMPLETED", "phase": "NA", "start_date": "2012-12", "completion_date": "2013-11", "months_since_completion": "154", "enrollment": "13", "sponsor_name": "Aleva Neurotherapeutics SA", "sponsor_class": "INDUSTRY", "sponsor_class_label": "Industry", "results_posted": "no", "due_12m": "yes", "classification": "FOUND_RESULTS", "classification_label": "Results publication located", "match_basis": "SPECIFICS_MATCH", "pmid": "24844728", "doi": "10.1093/brain/awu102", "url_opened": "https://pubmed.ncbi.nlm.nih.gov/24844728/", "pub_title": "Directional deep brain stimulation: an intraoperative double-blind pilot study", "pub_year": "2014", "journal": "Brain", "rationale": "Pollo (Bern) intraoperative directional stimulation in 11 PD + 2 ET = 13 patients matches registry; PMID 33192384 cites NCT01764815 for a sub-analysis", "registry_url": "https://clinicaltrials.gov/study/NCT01764815", "anchor": "https://et-trials-tracker.xyz/#NCT01764815" }, { "nct_id": "NCT01698450", "title": "Magnetic Resonance (MR) Guided Functional Ultrasound-Neurosurgery for Movement Disorders", "conditions": "Essential Tremor; Dystonia; Parkinson's Disease", "status": "COMPLETED", "phase": "PHASE1", "start_date": "2012-11", "completion_date": "2013-12", "months_since_completion": "153", "enrollment": "10", "sponsor_name": "University Children's Hospital, Zurich", "sponsor_class": "OTHER", "sponsor_class_label": "Other", "results_posted": "no", "due_12m": "yes", "classification": "UNCERTAIN", "classification_label": "Uncertain", "match_basis": "NONE", "pmid": "28275083", "doi": "10.1212/WNL.0000000000003795", "url_opened": "https://pubmed.ncbi.nlm.nih.gov/28275083/", "pub_title": "Unilateral cerebellothalamic tract ablation in essential tremor by MRI-guided focused ultrasound", "pub_year": "2017", "journal": "Neurology", "rationale": "Schreglmann 2017 (6 ET patients, Zurich/St Gallen investigators) is plausible but treatment dates and target could not be reconciled with the registered 10-patient multi-target study", "registry_url": "https://clinicaltrials.gov/study/NCT01698450", "anchor": "https://et-trials-tracker.xyz/#NCT01698450" }, { "nct_id": "NCT02037217", "title": "ExAblate Transcranial MR Guided Focused Ultrasound in the Treatment of Essential Tremor", "conditions": "Essential Tremor", "status": "COMPLETED", "phase": "PHASE1", "start_date": "2011-02", "completion_date": "2014-01", "months_since_completion": "152", "enrollment": "10", "sponsor_name": "InSightec", "sponsor_class": "INDUSTRY", "sponsor_class_label": "Industry", "results_posted": "no", "due_12m": "yes", "classification": "FOUND_RESULTS", "classification_label": "Results publication located", "match_basis": "SPECIFICS_MATCH", "pmid": "24876191", "doi": "10.1136/jnnp-2014-307642", "url_opened": "https://pubmed.ncbi.nlm.nih.gov/24876191/", "pub_title": "Unilateral magnetic resonance guided focused ultrasound thalamotomy for essential tremor: practices and clinicoradiological outcomes", "pub_year": "2015", "journal": "J Neurol Neurosurg Psychiatry", "rationale": "Chang/Chang Yonsei feasibility study (11 attempted, 8 treated) with InSightec coauthors matches the InSightec-sponsored feasibility study at Yonsei", "registry_url": "https://clinicaltrials.gov/study/NCT02037217", "anchor": "https://et-trials-tracker.xyz/#NCT02037217" }, { "nct_id": "NCT02947841", "title": "The Effectiveness of Alternating Stimulation in Preventing Tolerance in Essential Tremor Patients", "conditions": "Essential Tremor; Deep Brain Stimulation", "status": "COMPLETED", "phase": "NA", "start_date": "2016-10", "completion_date": "2017-07", "months_since_completion": "110", "enrollment": "22", "sponsor_name": "Oregon Health and Science University", "sponsor_class": "OTHER", "sponsor_class_label": "Other", "results_posted": "no", "due_12m": "yes", "classification": "FOUND_RESULTS", "classification_label": "Results publication located", "match_basis": "NCT_ID_MATCH", "pmid": "30637283", "doi": "10.1002/mdc3.12685", "url_opened": "https://pubmed.ncbi.nlm.nih.gov/30637283/", "pub_title": "Alternating Thalamic Deep Brain Stimulation for Essential Tremor: A Trial to Reduce Habituation", "pub_year": "2018", "journal": "Mov Disord Clin Pract", "rationale": "Europe PMC indexed the NCT ID to this paper; abstract matches registry exactly: OHSU, randomized placebo-controlled, 22 enrolled, TETRAS primary at 12 weeks", "registry_url": "https://clinicaltrials.gov/study/NCT02947841", "anchor": "https://et-trials-tracker.xyz/#NCT02947841" }, { "nct_id": "NCT02346409", "title": "Cerebello-thalamo-cortical Coupling in Essential Tremor", "conditions": "Essential Tremor", "status": "COMPLETED", "phase": "NA", "start_date": "2015-02-04", "completion_date": "2018-02-16", "months_since_completion": "103", "enrollment": "20", "sponsor_name": "Institut National de la Santé Et de la Recherche Médicale, France", "sponsor_class": "OTHER_GOV", "sponsor_class_label": "Other government", "results_posted": "no", "due_12m": "yes", "classification": "FOUND_RESULTS", "classification_label": "Results publication located", "match_basis": "SPECIFICS_MATCH", "pmid": "37097344", "doi": "10.1007/s13311-023-01372-6", "url_opened": "https://pubmed.ncbi.nlm.nih.gov/37097344/", "pub_title": "Cerebellar Transcranial Alternating Current Stimulation in Essential Tremor Patients with Thalamic Stimulation: A Proof-of-Concept Study", "pub_year": "2023", "journal": "Neurotherapeutics", "rationale": "ClinicalTrials.gov record itself lists this paper as its RESULT reference; Paris Brain Institute, 21 patients vs 20 registered, matches official title exactly", "registry_url": "https://clinicaltrials.gov/study/NCT02346409", "anchor": "https://et-trials-tracker.xyz/#NCT02346409" }, { "nct_id": "NCT02052271", "title": "Experimental Therapeutics in Essential Tremor Using Cerebellar Transcranial Direct Current Stimulation", "conditions": "Essential Tremor", "status": "COMPLETED", "phase": "NA", "start_date": "2014-06-03", "completion_date": "2018-03-27", "months_since_completion": "102", "enrollment": "16", "sponsor_name": "Institut National de la Santé Et de la Recherche Médicale, France", "sponsor_class": "OTHER_GOV", "sponsor_class_label": "Other government", "results_posted": "no", "due_12m": "yes", "classification": "NOT_FOUND", "classification_label": "No results publication located", "match_basis": "NONE", "pmid": "", "doi": "", "url_opened": "", "pub_title": "", "pub_year": "", "journal": "", "rationale": "No NCT hit; no registry references; keyword searches for cathodal cerebellar tDCS in ET (Paris, 2017-2025) returned only the tACS paper for NCT02346409 and reviews", "registry_url": "https://clinicaltrials.gov/study/NCT02052271", "anchor": "https://et-trials-tracker.xyz/#NCT02052271" }, { "nct_id": "NCT02704793", "title": "Cerebellar rTMS for Essential Tremor", "conditions": "Essential Tremor", "status": "COMPLETED", "phase": "NA", "start_date": "2016-04", "completion_date": "2018-05", "months_since_completion": "100", "enrollment": "23", "sponsor_name": "Mashhad University of Medical Sciences", "sponsor_class": "OTHER", "sponsor_class_label": "Other", "results_posted": "no", "due_12m": "yes", "classification": "FOUND_RESULTS", "classification_label": "Results publication located", "match_basis": "SPECIFICS_MATCH", "pmid": "31624048", "doi": "10.1016/j.brs.2019.10.003", "url_opened": "https://pubmed.ncbi.nlm.nih.gov/31624048/", "pub_title": "Cerebellar repetitive transcranial magnetic stimulation (rTMS) for essential tremor: A double-blind, sham-controlled, crossover, add-on clinical trial", "pub_year": "2020", "journal": "Brain Stimul", "rationale": "Mashhad paper (Shoeibi, the registry PI, co-author): 23 patients (registry 23), 1 Hz cerebellar rTMS vs sham crossover; NCT ID not in abstract", "registry_url": "https://clinicaltrials.gov/study/NCT02704793", "anchor": "https://et-trials-tracker.xyz/#NCT02704793" }, { "nct_id": "NCT03780426", "title": "tSMS in Essential Tremor", "conditions": "Essential Tremor", "status": "COMPLETED", "phase": "PHASE2", "start_date": "2018-10-01", "completion_date": "2019-12-01", "months_since_completion": "81", "enrollment": "30", "sponsor_name": "Fundación de investigación HM", "sponsor_class": "OTHER", "sponsor_class_label": "Other", "results_posted": "no", "due_12m": "yes", "classification": "FOUND_RESULTS", "classification_label": "Results publication located", "match_basis": "NCT_ID_MATCH", "pmid": "41298510", "doi": "10.1038/s41531-025-01182-x", "url_opened": "https://pubmed.ncbi.nlm.nih.gov/41298510/", "pub_title": "Transcranial static magnetic field stimulation of the primary motor cortex in essential tremor: a randomized pilot study", "pub_year": "2025", "journal": "NPJ Parkinsons Dis", "rationale": "Abstract states NCT03780426; 27 randomized, 23 analysed (registry 30)", "registry_url": "https://clinicaltrials.gov/study/NCT03780426", "anchor": "https://et-trials-tracker.xyz/#NCT03780426" }, { "nct_id": "NCT03935581", "title": "Safety and Feasibility of ExAblate Neuro System to Perform Auto-Focusing Echo Imaging in Patients With Essential Tremor", "conditions": "Tremor, Essential; Neurologic Manifestations; Tremor", "status": "COMPLETED", "phase": "NA", "start_date": "2019-04-25", "completion_date": "2020-04-28", "months_since_completion": "77", "enrollment": "20", "sponsor_name": "InSightec", "sponsor_class": "INDUSTRY", "sponsor_class_label": "Industry", "results_posted": "no", "due_12m": "yes", "classification": "FOUND_RESULTS", "classification_label": "Results publication located", "match_basis": "NCT_ID_MATCH", "pmid": "32815611", "doi": "10.1002/mds.28226", "url_opened": "https://pubmed.ncbi.nlm.nih.gov/32815611/", "pub_title": "Echo-Focusing in Transcranial Focused Ultrasound Thalamotomy for Essential Tremor: A Feasibility Study", "pub_year": "2020", "journal": "Mov Disord", "rationale": "Abstract cites NCT03935581; 12 Sunnybrook patients; second results paper from Yonsei (PMID 33510610) also carries the NCT ID, 8 patients; 12+8=20 matches registry", "registry_url": "https://clinicaltrials.gov/study/NCT03935581", "anchor": "https://et-trials-tracker.xyz/#NCT03935581" }, { "nct_id": "NCT02264925", "title": "Thalamic LFPs and VIM DBS in Essential Tremor: Correlation, Evolution, and Therapeutic Perspectives", "conditions": "Essential Tremor", "status": "COMPLETED", "phase": "NA", "start_date": "2014-11", "completion_date": "2020-11-19", "months_since_completion": "70", "enrollment": "12", "sponsor_name": "University Hospital, Bordeaux", "sponsor_class": "OTHER", "sponsor_class_label": "Other", "results_posted": "no", "due_12m": "yes", "classification": "FOUND_RESULTS", "classification_label": "Results publication located", "match_basis": "SPECIFICS_MATCH", "pmid": "38102180", "doi": "10.1038/s41598-023-49511-5", "url_opened": "https://pubmed.ncbi.nlm.nih.gov/38102180/", "pub_title": "Usefulness of thalamic beta activity for closed-loop therapy in essential tremor", "pub_year": "2023", "journal": "Sci Rep", "rationale": "Bordeaux paper (Guehl, Langbour, Burbaud = registry investigators): VIM LFP recordings with Activa PC+S in 10 ET patients (registry 12), 3-24 months; NCT ID not cited", "registry_url": "https://clinicaltrials.gov/study/NCT02264925", "anchor": "https://et-trials-tracker.xyz/#NCT02264925" }, { "nct_id": "NCT02960243", "title": "Deep Brain Stimulation for Voice Tremor: Left, Right, or Both Hemispheres?", "conditions": "Essential Voice Tremor; Deep Brain Stimulation; Essential Tremor; Laryngeal Diseases; Action Tremor; Tremor, Nerve", "status": "COMPLETED", "phase": "NA", "start_date": "2016-08", "completion_date": "2020-12", "months_since_completion": "69", "enrollment": "6", "sponsor_name": "University of British Columbia", "sponsor_class": "OTHER", "sponsor_class_label": "Other", "results_posted": "no", "due_12m": "yes", "classification": "FOUND_RESULTS", "classification_label": "Results publication located", "match_basis": "SPECIFICS_MATCH", "pmid": "30625492", "doi": "10.1159/000495413", "url_opened": "https://pubmed.ncbi.nlm.nih.gov/30625492/", "pub_title": "Unilateral Thalamic Deep Brain Stimulation for Voice Tremor", "pub_year": "2018", "journal": "Stereotact Funct Neurosurg", "rationale": "UBC paper matches registry design exactly (randomized blinded L/R/bilateral/OFF, voice ratings); 7 vs 6 registered; published two years before registry completion date; least secure FOUND row", "registry_url": "https://clinicaltrials.gov/study/NCT02960243", "anchor": "https://et-trials-tracker.xyz/#NCT02960243" }, { "nct_id": "NCT03875404", "title": "Next-Generation Pre-Operative Targeting for Thalamic DBS in the Treatment of Tremor", "conditions": "Essential Tremor", "status": "COMPLETED", "phase": "NA", "start_date": "2019-03-20", "completion_date": "2021-02-12", "months_since_completion": "67", "enrollment": "9", "sponsor_name": "Mayo Clinic", "sponsor_class": "OTHER", "sponsor_class_label": "Other", "results_posted": "no", "due_12m": "yes", "classification": "UNCERTAIN", "classification_label": "Uncertain", "match_basis": "NONE", "pmid": "34340623", "doi": "10.1177/19714009211036689", "url_opened": "https://pubmed.ncbi.nlm.nih.gov/34340623/", "pub_title": "Directed stimulation of the dentato-rubro-thalamic tract for deep brain stimulation in essential tremor: a blinded clinical trial", "pub_year": "2022", "journal": "Neuroradiol J", "rationale": "Mayo Florida (Middlebrooks, registry PI) blinded crossover in 6 ET patients, but uses diffusion tractography whereas registry intervention is functional MRI, enrolment 9, NCT not cited, full text not retrievable", "registry_url": "https://clinicaltrials.gov/study/NCT03875404", "anchor": "https://et-trials-tracker.xyz/#NCT03875404" }, { "nct_id": "NCT05480215", "title": "Symptomatic Relief of Action Tremor With Cala Trio Using Trio+ Bands", "conditions": "Essential Tremor; Parkinson Disease", "status": "COMPLETED", "phase": "NA", "start_date": "2021-10-07", "completion_date": "2021-12-16", "months_since_completion": "57", "enrollment": "20", "sponsor_name": "Cala Health, Inc.", "sponsor_class": "INDUSTRY", "sponsor_class_label": "Industry", "results_posted": "no", "due_12m": "yes", "classification": "NOT_FOUND", "classification_label": "No results publication located", "match_basis": "NONE", "pmid": "", "doi": "", "url_opened": "", "pub_title": "", "pub_year": "", "journal": "", "rationale": "No NCT hit; searches for Cala Trio Trio+ bands (2021-2026) returned only RWE studies, a pragmatic RCT, reviews and a case report, none a 20-patient band study", "registry_url": "https://clinicaltrials.gov/study/NCT05480215", "anchor": "https://et-trials-tracker.xyz/#NCT05480215" }, { "nct_id": "NCT05177900", "title": "Interphase Gap in Biphasic Stimulation in DBS for ET", "conditions": "Essential Tremor", "status": "COMPLETED", "phase": "NA", "start_date": "2021-12-01", "completion_date": "2022-01-27", "months_since_completion": "56", "enrollment": "9", "sponsor_name": "Myles Mc Laughlin", "sponsor_class": "OTHER", "sponsor_class_label": "Other", "results_posted": "no", "due_12m": "yes", "classification": "FOUND_RESULTS", "classification_label": "Results publication located", "match_basis": "NCT_ID_MATCH", "pmid": "36404213", "doi": "10.1016/j.neurom.2022.09.012", "url_opened": "https://pubmed.ncbi.nlm.nih.gov/36404213/", "pub_title": "Interphase Gaps in Symmetric Biphasic Pulses Reduce the Therapeutic Window in Ventral Intermediate Nucleus of the Thalamus-Deep Brain Stimulation for Essential Tremor", "pub_year": "2023", "journal": "Neuromodulation", "rationale": "Abstract states registration NCT05177900; KU Leuven, 9 patients (registry 9)", "registry_url": "https://clinicaltrials.gov/study/NCT05177900", "anchor": "https://et-trials-tracker.xyz/#NCT05177900" }, { "nct_id": "NCT02443181", "title": "Demand-driven Management of Essential Tremor", "conditions": "Essential Tremor", "status": "COMPLETED", "phase": "NA", "start_date": "2015-02", "completion_date": "2022-02", "months_since_completion": "55", "enrollment": "5", "sponsor_name": "University of Washington", "sponsor_class": "OTHER", "sponsor_class_label": "Other", "results_posted": "no", "due_12m": "yes", "classification": "FOUND_RESULTS", "classification_label": "Results publication located", "match_basis": "NCT_ID_MATCH", "pmid": "34955714", "doi": "10.3389/fnins.2021.749705", "url_opened": "https://pubmed.ncbi.nlm.nih.gov/34955714/", "pub_title": "Closing the Loop With Cortical Sensing: The Development of Adaptive Deep Brain Stimulation for Essential Tremor Using the Activa PC+S", "pub_year": "2021", "journal": "Front Neurosci", "rationale": "Full text identifies the study as conducted under NCT02443181 (UW, Activa PC+S) and summarises results from four participants; written as a programme summary, primary data papers do not cite the NCT", "registry_url": "https://clinicaltrials.gov/study/NCT02443181", "anchor": "https://et-trials-tracker.xyz/#NCT02443181" }, { "nct_id": "NCT04725045", "title": "Investigating the Use of Complex Pulse Shapes for DBS in Movement Disorders", "conditions": "Parkinson Disease; Essential Tremor", "status": "COMPLETED", "phase": "NA", "start_date": "2019-02-12", "completion_date": "2022-04-14", "months_since_completion": "53", "enrollment": "28", "sponsor_name": "KU Leuven", "sponsor_class": "OTHER", "sponsor_class_label": "Other", "results_posted": "no", "due_12m": "yes", "classification": "FOUND_RESULTS", "classification_label": "Results publication located", "match_basis": "NCT_ID_MATCH", "pmid": "38721121", "doi": "10.3389/fneur.2024.1366227", "url_opened": "https://pubmed.ncbi.nlm.nih.gov/38721121/", "pub_title": "Testing of symmetric biphasic stimulation in Vim-DBS ET patients: a randomized-controlled pilot study", "pub_year": "2024", "journal": "Front Neurol", "rationale": "Full text methods state NCT04725045; KU Leuven randomized double-blind crossover in 7 ET patients (registry 28 covers a broader programme)", "registry_url": "https://clinicaltrials.gov/study/NCT04725045", "anchor": "https://et-trials-tracker.xyz/#NCT04725045" }, { "nct_id": "NCT05157321", "title": "Repetitive Transcranial Magnetic Stimulation in Essential Tremors Patients", "conditions": "Essential Tremor", "status": "COMPLETED", "phase": "NA", "start_date": "2021-12-10", "completion_date": "2022-04-30", "months_since_completion": "53", "enrollment": "30", "sponsor_name": "Al-Azhar University", "sponsor_class": "OTHER", "sponsor_class_label": "Other", "results_posted": "no", "due_12m": "yes", "classification": "FOUND_RESULTS", "classification_label": "Results publication located", "match_basis": "NCT_ID_MATCH", "pmid": "38951972", "doi": "10.3988/jcn.2023.0348", "url_opened": "https://pubmed.ncbi.nlm.nih.gov/38951972/", "pub_title": "Efficacy of Cerebellar Transcranial Magnetic Stimulation in Treating Essential Tremor: A Randomized, Sham-Controlled Trial", "pub_year": "2024", "journal": "J Clin Neurol", "rationale": "Full text: protocol registered NCT05157321; Al-Azhar sham-controlled cerebellar rTMS RCT; 45 analysed vs 30 registered", "registry_url": "https://clinicaltrials.gov/study/NCT05157321", "anchor": "https://et-trials-tracker.xyz/#NCT05157321" }, { "nct_id": "NCT04661241", "title": "Mapping the Target for the MRgFUS Treatment of Tremor", "conditions": "Tremor, Essential; Parkinson's Disease", "status": "COMPLETED", "phase": "NA", "start_date": "2020-09-10", "completion_date": "2022-06-15", "months_since_completion": "51", "enrollment": "6", "sponsor_name": "NYU Langone Health", "sponsor_class": "OTHER", "sponsor_class_label": "Other", "results_posted": "no", "due_12m": "yes", "classification": "NOT_FOUND", "classification_label": "No results publication located", "match_basis": "NONE", "pmid": "", "doi": "", "url_opened": "", "pub_title": "", "pub_year": "", "journal": "", "rationale": "No NCT hit; NYU MRgFUS targeting searches found only a retrospective 23-patient tractography comparison and case reports, none the 6-subject targeting study", "registry_url": "https://clinicaltrials.gov/study/NCT04661241", "anchor": "https://et-trials-tracker.xyz/#NCT04661241" }, { "nct_id": "NCT04880616", "title": "Safety, Efficacy, and Tolerability of NBI-827104 for the Treatment of Essential Tremor", "conditions": "Essential Tremor", "status": "COMPLETED", "phase": "PHASE2", "start_date": "2021-04-20", "completion_date": "2022-06-08", "months_since_completion": "51", "enrollment": "31", "sponsor_name": "Neurocrine Biosciences", "sponsor_class": "INDUSTRY", "sponsor_class_label": "Industry", "results_posted": "no", "due_12m": "yes", "classification": "MENTIONED_ONLY", "classification_label": "Cited in literature only", "match_basis": "NCT_ID_MATCH", "pmid": "40415659", "doi": "10.1002/mdc3.70147", "url_opened": "https://pubmed.ncbi.nlm.nih.gov/40415659/", "pub_title": "Current and Emerging Therapeutic Targets for Essential Tremor: A Critical Appraisal of Recent Preclinical and Clinical Studies", "pub_year": "2025", "journal": "Mov Disord Clin Pract", "rationale": "NCT04880616 appears only in two reviews; review states NBI-827104 failed its efficacy endpoints citing only an MDS 2023 conference abstract; no peer-reviewed results paper", "registry_url": "https://clinicaltrials.gov/study/NCT04880616", "anchor": "https://et-trials-tracker.xyz/#NCT04880616" }, { "nct_id": "NCT05106816", "title": "The Effects of Vibrotactile Stimulation in Patients With Movement Disorders", "conditions": "Parkinson Disease; Essential Tremor; Dystonia", "status": "COMPLETED", "phase": "NA", "start_date": "2021-10-07", "completion_date": "2022-09-20", "months_since_completion": "48", "enrollment": "40", "sponsor_name": "University of Florida", "sponsor_class": "OTHER", "sponsor_class_label": "Other", "results_posted": "no", "due_12m": "yes", "classification": "NOT_FOUND", "classification_label": "No results publication located", "match_basis": "NONE", "pmid": "", "doi": "", "url_opened": "", "pub_title": "", "pub_year": "", "journal": "", "rationale": "No NCT hit; searches for vibrotactile stimulation at UF Fixel Institute found only an unrelated Radboud/UF study, not the 40-patient sham-controlled Vibrohealth study", "registry_url": "https://clinicaltrials.gov/study/NCT05106816", "anchor": "https://et-trials-tracker.xyz/#NCT05106816" }, { "nct_id": "NCT06847581", "title": "JAME, a Wearable Device to Control Tremor", "conditions": "Parkinson Disease; Essential Tremor", "status": "COMPLETED", "phase": "NA", "start_date": "2022-03-03", "completion_date": "2022-10-10", "months_since_completion": "47", "enrollment": "14", "sponsor_name": "Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico", "sponsor_class": "OTHER", "sponsor_class_label": "Other", "results_posted": "no", "due_12m": "yes", "classification": "NOT_FOUND", "classification_label": "No results publication located", "match_basis": "NONE", "pmid": "", "doi": "", "url_opened": "", "pub_title": "", "pub_year": "", "journal": "", "rationale": "No NCT hit; searches for JAME wearable tremor device (Policlinico Milan, 2021-2026) returned nothing relevant", "registry_url": "https://clinicaltrials.gov/study/NCT06847581", "anchor": "https://et-trials-tracker.xyz/#NCT06847581" }, { "nct_id": "NCT06314139", "title": "Tolerability and Efficacy of Continuous Theta-burst Stimulation for Essential Tremor: A Randomized Study.", "conditions": "Essential Tremor; Continuous Theta Burst Stimulation", "status": "COMPLETED", "phase": "NA", "start_date": "2022-09-01", "completion_date": "2023-06-01", "months_since_completion": "39", "enrollment": "60", "sponsor_name": "West China Hospital", "sponsor_class": "OTHER", "sponsor_class_label": "Other", "results_posted": "no", "due_12m": "yes", "classification": "FOUND_RESULTS", "classification_label": "Results publication located", "match_basis": "SPECIFICS_MATCH", "pmid": "41319505", "doi": "10.1016/j.nicl.2025.103918", "url_opened": "https://pubmed.ncbi.nlm.nih.gov/41319505/", "pub_title": "Acute effects of a single session of multitarget continuous Theta-Burst stimulation for essential Tremor: A Randomized, Sham-Controlled trial.", "pub_year": "2025", "journal": "Neuroimage Clin", "rationale": "Paper cites ChiCTR2200064037 not the NCT; West China Hospital cTBS vs sham n=60, FTM-TRS timepoints and start 2022-09 match the record line by line; NCT registered retrospectively in 2024", "registry_url": "https://clinicaltrials.gov/study/NCT06314139", "anchor": "https://et-trials-tracker.xyz/#NCT06314139" }, { "nct_id": "NCT04658641", "title": "Characterization of Complex Pulse Shapes in Deep Brain Stimulation for Movement Disorders Using EEG and Local Field Potential Recordings", "conditions": "Parkinson Disease; Essential Tremor", "status": "COMPLETED", "phase": "NA", "start_date": "2020-12-14", "completion_date": "2023-06-20", "months_since_completion": "39", "enrollment": "30", "sponsor_name": "KU Leuven", "sponsor_class": "OTHER", "sponsor_class_label": "Other", "results_posted": "no", "due_12m": "yes", "classification": "FOUND_RESULTS", "classification_label": "Results publication located", "match_basis": "NCT_ID_MATCH", "pmid": "35088733", "doi": "10.1016/j.neurom.2021.11.002", "url_opened": "https://pubmed.ncbi.nlm.nih.gov/35088733/", "pub_title": "Electrophysiologic Evidence That Directional Deep Brain Stimulation Activates Distinct Neural Circuits in Patients With Parkinson Disease.", "pub_year": "2023", "journal": "Neuromodulation", "rationale": "KU Leuven umbrella study (PD and ET); three papers state registration NCT04658641 and report results from the PD participants only; no paper reporting the ET participants found", "registry_url": "https://clinicaltrials.gov/study/NCT04658641", "anchor": "https://et-trials-tracker.xyz/#NCT04658641" }, { "nct_id": "NCT04361955", "title": "Modulatory Effects of Deep Brain Stimulation on Cerebral Cortical Activity", "conditions": "DBS; Parkinson Disease; Essential Tremor; Healthy", "status": "COMPLETED", "phase": "NA", "start_date": "2020-01-31", "completion_date": "2023-08-10", "months_since_completion": "37", "enrollment": "66", "sponsor_name": "The Cleveland Clinic", "sponsor_class": "OTHER", "sponsor_class_label": "Other", "results_posted": "no", "due_12m": "yes", "classification": "FOUND_RESULTS", "classification_label": "Results publication located", "match_basis": "NCT_ID_MATCH", "pmid": "41710158", "doi": "10.3389/fnins.2026.1733633", "url_opened": "https://pubmed.ncbi.nlm.nih.gov/41710158/", "pub_title": "Evaluation of the myogenic effects of subthalamic nucleus deep brain stimulation at near therapeutic amplitudes.", "pub_year": "2026", "journal": "Front Neurosci", "rationale": "Cleveland Clinic paper states procedures were performed under NCT04361955; reports EMG results from 16 STN-DBS PD participants, a subset of this 66-person multi-cohort protocol; no ET-cohort paper found", "registry_url": "https://clinicaltrials.gov/study/NCT04361955", "anchor": "https://et-trials-tracker.xyz/#NCT04361955" }, { "nct_id": "NCT03760406", "title": "Optimization of VIM Targeting in Essential Tremor Surgery", "conditions": "Essential Tremor", "status": "COMPLETED", "phase": "NA", "start_date": "2019-03-18", "completion_date": "2023-08-29", "months_since_completion": "37", "enrollment": "22", "sponsor_name": "University Hospital, Bordeaux", "sponsor_class": "OTHER", "sponsor_class_label": "Other", "results_posted": "no", "due_12m": "yes", "classification": "FOUND_RESULTS", "classification_label": "Results publication located", "match_basis": "SPECIFICS_MATCH", "pmid": "41626878", "doi": "10.1227/neu.0000000000003870", "url_opened": "https://pubmed.ncbi.nlm.nih.gov/41626878/", "pub_title": "Enhancing Asleep Deep Brain Stimulation Targeting for Essential Tremor Using Machine Learning: The OPTIVIM Phase 2 Study.", "pub_year": "2025", "journal": "Neurosurgery", "rationale": "NCT ID absent from full text but ClinicalTrials.gov links this paper as a RESULT reference; OPTIVIM phase 2, 22 patients from Bordeaux and Lyon, FTM at 3 months", "registry_url": "https://clinicaltrials.gov/study/NCT03760406", "anchor": "https://et-trials-tracker.xyz/#NCT03760406" }, { "nct_id": "NCT05021991", "title": "A Clinical Trial of 2 Doses of PRAX-944 in Participants With Essential Tremor", "conditions": "Essential Tremor", "status": "COMPLETED", "phase": "PHASE2", "start_date": "2021-10-14", "completion_date": "2024-02-29", "months_since_completion": "31", "enrollment": "133", "sponsor_name": "Praxis Precision Medicines", "sponsor_class": "INDUSTRY", "sponsor_class_label": "Industry", "results_posted": "no", "due_12m": "yes", "classification": "MENTIONED_ONLY", "classification_label": "Cited in literature only", "match_basis": "NONE", "pmid": "36738196", "doi": "10.1002/acn3.51735", "url_opened": "https://pubmed.ncbi.nlm.nih.gov/36738196/", "pub_title": "T-type calcium channels as therapeutic targets in essential tremor and Parkinson's disease.", "pub_year": "2023", "journal": "Ann Clin Transl Neurol", "rationale": "Hits are a phase 1 PRAX-944 paper and reviews saying the phase 2 is underway; no phase 2 dose-range results paper for PRAX-944/ulixacaltamide found", "registry_url": "https://clinicaltrials.gov/study/NCT05021991", "anchor": "https://et-trials-tracker.xyz/#NCT05021991" }, { "nct_id": "NCT04720469", "title": "A Second Magnetic Resonance Guided Focused Ultrasound Thalamotomy for Essential Tremor", "conditions": "Essential Tremor", "status": "COMPLETED", "phase": "NA", "start_date": "2020-10-05", "completion_date": "2024-03-18", "months_since_completion": "30", "enrollment": "11", "sponsor_name": "Sunnybrook Health Sciences Centre", "sponsor_class": "OTHER", "sponsor_class_label": "Other", "results_posted": "no", "due_12m": "yes", "classification": "FOUND_RESULTS", "classification_label": "Results publication located", "match_basis": "NCT_ID_MATCH", "pmid": "37868927", "doi": "10.1002/mdc3.13882", "url_opened": "https://pubmed.ncbi.nlm.nih.gov/37868927/", "pub_title": "Safety of Bilateral Staged Magnetic Resonance-Guided Focused Ultrasound Thalamotomy for Essential Tremor.", "pub_year": "2023", "journal": "Mov Disord Clin Pract", "rationale": "Sunnybrook letter states this prospective open-label trial (NCT04720469) screened 16, 11 underwent MRgFUS 2 (= registry enrolment); reports CRST change and adverse events", "registry_url": "https://clinicaltrials.gov/study/NCT04720469", "anchor": "https://et-trials-tracker.xyz/#NCT04720469" }, { "nct_id": "NCT05540626", "title": "RWE Study Utilizing the Cala Trio Device in Patients With Essential Tremor", "conditions": "Essential Tremor", "status": "COMPLETED", "phase": "NA", "start_date": "2021-04-08", "completion_date": "2024-03-01", "months_since_completion": "30", "enrollment": "276", "sponsor_name": "Cala Health, Inc.", "sponsor_class": "INDUSTRY", "sponsor_class_label": "Industry", "results_posted": "no", "due_12m": "yes", "classification": "FOUND_RESULTS", "classification_label": "Results publication located", "match_basis": "NCT_ID_MATCH", "pmid": "37869579", "doi": "10.5334/tohm.798", "url_opened": "https://pubmed.ncbi.nlm.nih.gov/37869579/", "pub_title": "Comparative Effectiveness of Transcutaneous Afferent Patterned Stimulation Therapy for Essential Tremor: A Randomized Pragmatic Clinical Trial.", "pub_year": "2023", "journal": "Tremor Other Hyperkinet Mov (N Y)", "rationale": "Full text: registered NCT05540626; Cala Health + CVS authors, 310 randomized, 276 completers (= registry 276)", "registry_url": "https://clinicaltrials.gov/study/NCT05540626", "anchor": "https://et-trials-tracker.xyz/#NCT05540626" }, { "nct_id": "NCT06036368", "title": "Study to Evaluate Safety and Efficacy of Peroneal Transcutaneous NeuroModulation in Subjects With Parkinson's Disease and Essential Tremor", "conditions": "Parkinson's Disease; Essential Tremor", "status": "COMPLETED", "phase": "NA", "start_date": "2023-09-15", "completion_date": "2024-06-30", "months_since_completion": "27", "enrollment": "23", "sponsor_name": "Stimvia s.r.o.", "sponsor_class": "INDUSTRY", "sponsor_class_label": "Industry", "results_posted": "no", "due_12m": "yes", "classification": "FOUND_RESULTS", "classification_label": "Results publication located", "match_basis": "NCT_ID_MATCH", "pmid": "40271391", "doi": "10.1016/j.prdoa.2025.100321", "url_opened": "https://pubmed.ncbi.nlm.nih.gov/40271391/", "pub_title": "Home-based peroneal electrical transcutaneous NeuroModulation (peroneal eTNM) in Parkinson's disease as add-on treatment - Results of a pilot study.", "pub_year": "2025", "journal": "Clin Park Relat Disord", "rationale": "Full text cites the NCT with a typo (NTC06036368), which is why ID searches returned nothing; reports only the 12 PD participants of the 23 enrolled (PD + ET); no ET-arm publication found", "registry_url": "https://clinicaltrials.gov/study/NCT06036368", "anchor": "https://et-trials-tracker.xyz/#NCT06036368" }, { "nct_id": "NCT07526155", "title": "Clinical Trial to Compare VIM vs PSA Bilateral Deep Brain Stimulation in Patients With Essential Tremor", "conditions": "Essential Tremor (ET)", "status": "COMPLETED", "phase": "NA", "start_date": "2020-05-27", "completion_date": "2024-07-24", "months_since_completion": "26", "enrollment": "11", "sponsor_name": "Fundación Pública Andaluza para la Investigación Biomédica Andalucía Oriental", "sponsor_class": "OTHER", "sponsor_class_label": "Other", "results_posted": "no", "due_12m": "yes", "classification": "UNCERTAIN", "classification_label": "Uncertain", "match_basis": "NCT_ID_MATCH", "pmid": "42621918", "doi": "10.3389/fneur.2026.1865673", "url_opened": "https://pubmed.ncbi.nlm.nih.gov/42621918/", "pub_title": "Dual-target VIM-PSA deep brain stimulation using octopolar electrodes: surgical technique and feasibility study.", "pub_year": "2026", "journal": "Front Neurol", "rationale": "Granada paper cites NCT07526155 and reports surgical accuracy and early safety for the same 11 patients, but explicitly states the crossover efficacy data were not assessed and describes the trial as ongoing", "registry_url": "https://clinicaltrials.gov/study/NCT07526155", "anchor": "https://et-trials-tracker.xyz/#NCT07526155" }, { "nct_id": "NCT04265209", "title": "[18F] LBT-999 PET Compared to [123I]-FP/CIT SPECT to Distinguish Between Parkinson's Diseases and Essential Tremor", "conditions": "Parkinson Disease; Essential Tremor", "status": "COMPLETED", "phase": "PHASE3", "start_date": "2021-12-01", "completion_date": "2024-08-02", "months_since_completion": "25", "enrollment": "152", "sponsor_name": "GE Healthcare", "sponsor_class": "INDUSTRY", "sponsor_class_label": "Industry", "results_posted": "no", "due_12m": "yes", "classification": "NOT_FOUND", "classification_label": "No results publication located", "match_basis": "NONE", "pmid": "", "doi": "", "url_opened": "", "pub_title": "", "pub_year": "", "journal": "", "rationale": "No NCT hit; keyword searches for [18F]LBT-999 return only earlier small Tours studies and radiochemistry; no GE Healthcare 152-patient phase 3 PD-vs-ET comparison found", "registry_url": "https://clinicaltrials.gov/study/NCT04265209", "anchor": "https://et-trials-tracker.xyz/#NCT04265209" }, { "nct_id": "NCT05956223", "title": "The Development of a System for Measurement of Tremor", "conditions": "Essential Tremor; Dystonia", "status": "COMPLETED", "phase": "NA", "start_date": "2023-11-30", "completion_date": "2024-11-20", "months_since_completion": "22", "enrollment": "43", "sponsor_name": "The Bionics Institute of Australia", "sponsor_class": "OTHER", "sponsor_class_label": "Other", "results_posted": "no", "due_12m": "yes", "classification": "NOT_FOUND", "classification_label": "No results publication located", "match_basis": "NONE", "pmid": "", "doi": "", "url_opened": "", "pub_title": "", "pub_year": "", "journal": "", "rationale": "No NCT hit; searches for VR tremor measurement (Szmulewicz, Bionics Institute) returned nothing reporting a 43-participant system", "registry_url": "https://clinicaltrials.gov/study/NCT05956223", "anchor": "https://et-trials-tracker.xyz/#NCT05956223" }, { "nct_id": "NCT06343285", "title": "Upper Limb Tremor Reduction in Essential Tremor Patients", "conditions": "Essential Tremor", "status": "COMPLETED", "phase": "NA", "start_date": "2024-01-01", "completion_date": "2024-11-12", "months_since_completion": "22", "enrollment": "71", "sponsor_name": "Encora, Inc.", "sponsor_class": "INDUSTRY", "sponsor_class_label": "Industry", "results_posted": "no", "due_12m": "yes", "classification": "MENTIONED_ONLY", "classification_label": "Cited in literature only", "match_basis": "NONE", "pmid": "39553441", "doi": "10.5334/tohm.930", "url_opened": "https://pubmed.ncbi.nlm.nih.gov/39553441/", "pub_title": "Shaking Up Essential Tremor: Peripheral Devices and Mechanical Strategies to Reduce Tremor.", "pub_year": "2024", "journal": "Tremor Other Hyperkinet Mov (N Y)", "rationale": "Review says of the Encora device: a larger sham-controlled trial has been completed but not presented (NCT06343285); no results paper", "registry_url": "https://clinicaltrials.gov/study/NCT06343285", "anchor": "https://et-trials-tracker.xyz/#NCT06343285" }, { "nct_id": "NCT05216250", "title": "Study of BOTOX Injections to Assess Change in Disease Symptoms in Adult Participants With Upper Limb Essential Tremor", "conditions": "Upper Limb Essential Tremor (UL ET)", "status": "COMPLETED", "phase": "PHASE2", "start_date": "2022-04-12", "completion_date": "2025-02-03", "months_since_completion": "19", "enrollment": "174", "sponsor_name": "AbbVie", "sponsor_class": "INDUSTRY", "sponsor_class_label": "Industry", "results_posted": "no", "due_12m": "yes", "classification": "MENTIONED_ONLY", "classification_label": "Cited in literature only", "match_basis": "NONE", "pmid": "42729179", "doi": "10.3389/fneur.2026.1886329", "url_opened": "https://pubmed.ncbi.nlm.nih.gov/42729179/", "pub_title": "Efficacy and safety of botulinum toxin type a for upper-limb essential tremor: a systematic review and meta-analysis of randomized placebo-controlled trials.", "pub_year": "2026", "journal": "Front Neurol", "rationale": "Only hit is a 2026 meta-analysis whose full text says ELATE/NCT05216250 was summarised narratively because registry, sponsor and conference sources did not provide a complete dataset; no peer-reviewed results as of 2026", "registry_url": "https://clinicaltrials.gov/study/NCT05216250", "anchor": "https://et-trials-tracker.xyz/#NCT05216250" }, { "nct_id": "NCT06397391", "title": "Nonlinear Absorber in Essential Tremor Treatment", "conditions": "Essential Tremor", "status": "COMPLETED", "phase": "NA", "start_date": "2024-08-30", "completion_date": "2025-04-04", "months_since_completion": "17", "enrollment": "5", "sponsor_name": "Hospices Civils de Lyon", "sponsor_class": "OTHER", "sponsor_class_label": "Other", "results_posted": "no", "due_12m": "yes", "classification": "MENTIONED_ONLY", "classification_label": "Cited in literature only", "match_basis": "NONE", "pmid": "40415659", "doi": "10.1002/mdc3.70147", "url_opened": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=NCT06397391&format=json", "pub_title": "Current and Emerging Therapeutic Targets for Essential Tremor: A Critical Appraisal of Recent Preclinical and Clinical Studies.", "pub_year": "2025", "journal": "Mov Disord Clin Pract", "rationale": "Sole hit is a narrative review via Europe PMC full-text index (XML returned HTTP 500 twice); 5-patient Lyon trial completed 2025-04; NOT_FOUND expected", "registry_url": "https://clinicaltrials.gov/study/NCT06397391", "anchor": "https://et-trials-tracker.xyz/#NCT06397391" }, { "nct_id": "NCT03465761", "title": "Staged Bilateral Exablate Treatment of Medication Refractory Essential Tremor", "conditions": "Essential Tremor", "status": "COMPLETED", "phase": "NA", "start_date": "2019-01-03", "completion_date": "2025-11-17", "months_since_completion": "10", "enrollment": "7", "sponsor_name": "InSightec", "sponsor_class": "INDUSTRY", "sponsor_class_label": "Industry", "results_posted": "no", "due_12m": "no", "classification": "UNCERTAIN", "classification_label": "Uncertain", "match_basis": "NONE", "pmid": "33906933", "doi": "10.1136/jnnp-2020-325278", "url_opened": "https://pubmed.ncbi.nlm.nih.gov/33906933/", "pub_title": "Bilateral staged magnetic resonance-guided focused ultrasound thalamotomy for the treatment of essential tremor: a case series study.", "pub_year": "2021", "journal": "J Neurol Neurosurg Psychiatry", "rationale": "NCT ID appears only in reviews; HM CINAC Insightec-funded staged bilateral FUS case series is plausibly the same programme but reports 9 patients from CINAC + Zurich (registry 7, CINAC + Imperial) and predates primary completion; not confirmable", "registry_url": "https://clinicaltrials.gov/study/NCT03465761", "anchor": "https://et-trials-tracker.xyz/#NCT03465761" }, { "nct_id": "NCT05671848", "title": "Electroclinical Correlates in Essential Tremor", "conditions": "Essential Tremor", "status": "COMPLETED", "phase": "NA", "start_date": "2023-05-03", "completion_date": "2025-11-26", "months_since_completion": "10", "enrollment": "10", "sponsor_name": "University Hospital, Bordeaux", "sponsor_class": "OTHER", "sponsor_class_label": "Other", "results_posted": "no", "due_12m": "no", "classification": "MENTIONED_ONLY", "classification_label": "Cited in literature only", "match_basis": "NONE", "pmid": "38004040", "doi": "10.3390/medicina59111991", "url_opened": "https://pubmed.ncbi.nlm.nih.gov/38004040/", "pub_title": "Deep Brain Stimulation for the Management of Refractory Neurological Disorders: A Comprehensive Review.", "pub_year": "2023", "journal": "Medicina (Kaunas)", "rationale": "Only hit is a review table listing NCT05671848; completed 2025-11; NOT_FOUND expected", "registry_url": "https://clinicaltrials.gov/study/NCT05671848", "anchor": "https://et-trials-tracker.xyz/#NCT05671848" }, { "nct_id": "NCT06403280", "title": "The Effect of Alcohol on Common Tremor Syndromes", "conditions": "Essential Tremor; Dystonia; Parkinson Disease", "status": "COMPLETED", "phase": "NA", "start_date": "2024-05-01", "completion_date": "2026-03-31", "months_since_completion": "6", "enrollment": "45", "sponsor_name": "Medical University of Graz", "sponsor_class": "OTHER", "sponsor_class_label": "Other", "results_posted": "no", "due_12m": "no", "classification": "NOT_FOUND", "classification_label": "No results publication located", "match_basis": "NONE", "pmid": "", "doi": "", "url_opened": "", "pub_title": "", "pub_year": "", "journal": "", "rationale": "No NCT hit; alcohol/tremor crossover searches 2024-2026 return nothing; completed 2026-03 so no publication expected yet", "registry_url": "https://clinicaltrials.gov/study/NCT06403280", "anchor": "https://et-trials-tracker.xyz/#NCT06403280" }, { "nct_id": "NCT00223743", "title": "A Safety/Efficacy Trial of Zonisamide for Essential Tremor", "conditions": "Essential Tremor", "status": "COMPLETED", "phase": "PHASE2", "start_date": "2004-11", "completion_date": "", "months_since_completion": "", "enrollment": "25", "sponsor_name": "VA Greater Los Angeles Healthcare System", "sponsor_class": "FED", "sponsor_class_label": "Other federal", "results_posted": "no", "due_12m": "", "classification": "FOUND_RESULTS", "classification_label": "Results publication located", "match_basis": "SPECIFICS_MATCH", "pmid": "19117357", "doi": "10.1002/mds.22418", "url_opened": "https://pubmed.ncbi.nlm.nih.gov/19117357/", "pub_title": "Zonisamide for essential tremor: an evaluator-blinded study.", "pub_year": "2009", "journal": "Mov Disord", "rationale": "No NCT-ID hit (2005-era registration); Handforth (VA GLA) single-site rising-dose zonisamide study with blinded video rating, n=25 (= registry enrolment), design matches registry", "registry_url": "https://clinicaltrials.gov/study/NCT00223743", "anchor": "https://et-trials-tracker.xyz/#NCT00223743" }, { "nct_id": "NCT01250067", "title": "Motor-related Cortical Potential in Patients With Essential Tremor", "conditions": "Essential Tremor; Movement-related Cortical Potentials", "status": "COMPLETED", "phase": "NA", "start_date": "2003-08", "completion_date": "", "months_since_completion": "", "enrollment": "", "sponsor_name": "China Medical University Hospital", "sponsor_class": "OTHER", "sponsor_class_label": "Other", "results_posted": "no", "due_12m": "", "classification": "UNCERTAIN", "classification_label": "Uncertain", "match_basis": "NONE", "pmid": "20097128", "doi": "10.1016/j.clinph.2009.12.014", "url_opened": "https://pubmed.ncbi.nlm.nih.gov/20097128/", "pub_title": "The Bereitschaftspotential in essential tremor.", "pub_year": "2010", "journal": "Clin Neurophysiol", "rationale": "Same lab, PI and funder as registry (China Medical University Hospital, Tsai), compares BP in ET vs controls, but published before the retrospective registration and source analysis not evident; cannot confirm", "registry_url": "https://clinicaltrials.gov/study/NCT01250067", "anchor": "https://et-trials-tracker.xyz/#NCT01250067" }, { "nct_id": "NCT01978080", "title": "Continuous Tremor Assessment During Daily Activities", "conditions": "Essential Tremor", "status": "COMPLETED", "phase": "NA", "start_date": "2013-10", "completion_date": "", "months_since_completion": "", "enrollment": "39", "sponsor_name": "Great Lakes NeuroTechnologies Inc.", "sponsor_class": "INDUSTRY", "sponsor_class_label": "Industry", "results_posted": "no", "due_12m": "", "classification": "FOUND_RESULTS", "classification_label": "Results publication located", "match_basis": "SPECIFICS_MATCH", "pmid": "30746399", "doi": "10.1002/mdc3.12554", "url_opened": "https://pubmed.ncbi.nlm.nih.gov/30746399/", "pub_title": "Does Added Objective Tremor Monitoring Improve Clinical Outcomes in Essential Tremor Treatment?", "pub_year": "2017", "journal": "Mov Disord Clin Pract", "rationale": "Europe PMC full-text term probes confirm randomized, blinded, Kinesia, CGI, Rush, Baylor, Great Lakes NeuroTechnologies, NIA, all matching registry; authors include registry PI (Heldman); n=39 unverified as full text blocked", "registry_url": "https://clinicaltrials.gov/study/NCT01978080", "anchor": "https://et-trials-tracker.xyz/#NCT01978080" } ] }